Other conditions are associated with EPI

EPI is a consequence of other diseases and procedures including1-8:

Patients with pancreatic cancer may have duct obstruction, atrophy of pancreatic tissue, or surgery that may cause EPI.

Partial or complete removal of the pancreas is very likely to cause EPI and the patient will need lifelong use of pancreatic enzyme replacement therapy (PERT). EPI has been diagnosed after partial resection of the pancreas including duodenopancreatectomy (Whipple procedure), a procedure that involves removal of the head of the pancreas and the encircling duodenum.

The risk of EPI depends upon the type of surgery and extent of pancreatic tissue removed

EPI can occur as a long-term complication of this rare, chronic fibro-inflammatory disease of the pancreas.

EPI may occur in some patients suffering from pancreatitis associated with IBD.

EPI is one condition that may cause chronic diarrhea in celiac patients.

While there may be an association between EPI and diabetes, the true incidence of EPI in diabetes is unknown, and the pathophysiology remains unclear.

References: 1. Keller J, Layer P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 2005;54(suppl 6):vi1-28. 2. Domínguez-Muñoz JE. Pancreatic enzyme therapy for pancreatic exocrine insufficiency. Curr Gastroenterol Rep. 2007;9(2):116-122. 3. Matsumoto J, Traverso LW. Exocrine function following the whipple operation as assessed by stool elastase. J Gastrointest Surg. 2006;10(9):1225-1229. 4. Yuasa Y, Murakami Y, Nakamura H, et al. Histological loss of pancreatic exocrine cells correlates with pancreatic exocrine function after pancreatic surgery. Pancreas. 2012;41(6):928-933. 5. Sah RP, Chari ST. Autoimmune pancreatitis: an update on classification, diagnosis, natural history and management. Curr Gastroenterol Rep. 2012;14(2):95-105. 6. Maconi G, Dominici R, Molteni M, et al. Prevalence of pancreatic insufficiency in inflammatory bowel diseases. Assessment by fecal elastase-1. Dig Dis Sci. 2008;53(1):262-270. 7. Leeds JS, Hopper AD, Hurlstone DP, et al. Is exocrine pancreatic insufficiency in adult coeliac disease a cause of persisting symptoms? Aliment Pharmacol Ther. 2007;25(3):265-271. 8. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003;26(suppl 1):S5-S20.