Patients with pancreatic cancer may have duct obstruction, atrophy of pancreatic tissue, or surgery that may cause EPI.
Partial or complete removal of the pancreas is very likely to cause EPI and the patient will need lifelong use of pancreatic enzyme replacement therapy (PERT). EPI has been diagnosed after partial resection of the pancreas including duodenopancreatectomy (Whipple procedure), a procedure that involves removal of the head of the pancreas and the encircling duodenum.
EPI can occur as a long-term complication of this rare, chronic fibro-inflammatory disease of the pancreas.
INFLAMMATORY BOWEL DISEASE:
EPI may occur in some patients suffering from pancreatitis associated with IBD.
EPI is one condition that may cause chronic diarrhea in celiac patients.
While there may be an association between EPI and diabetes, the true incidence of EPI in diabetes is unknown, and the pathophysiology remains unclear.