Management of EPI

Pancreatic enzyme replacement therapy is the basis of EPI management1,2

Pancreatic enzyme replacement therapies (PERTs) help deliver pancreatic enzyme concentrations into the duodenal lumen to help break down food for absorption.

  • Enzyme replacement therapy should ideally mimic the physiological pattern of pancreatic exocrine secretion, delivering active lipase into the duodenum together with food
  • Therefore it is important that PERTs are administered together with meals and snacks

Once your patients have started managing EPI, help them understand the impact treatment is having on their GI symptoms by having them fill out the GI Symptom Tracker and follow up 2 weeks later.

In addition to PERT treatment options, consider adding these elements to the patient treatment plan1,2:

  • A nutritionally well-balanced diet
  • Vitamin and mineral supplements, including fat-soluble vitamins A, D, E, and K
  • Lifestyle modifications
    • - Limit alcohol intake
    • - Smoking cessation
References: 1. Domínguez-Muñoz JE. Pancreatic enzyme therapy for pancreatic exocrine insufficiency. Curr Gastroenterol Rep. 2007;9(2):116-122. 2. Fieker A, Philpott J, Armand M. Enzyme replacement therapy for pancreatic insufficiency: present and future. Clin Exp Gastroenterol. 2011;4:55-73.