EPI is a manageable condition1-3

Once you have made a diagnosis of EPI, a comprehensive management plan should include pancreatic enzyme replacement therapy (PERT) along with certain lifestyle modifications. PERT is the standard of care for EPI.

Comprehensive EPI management plan1-3

Once an EPI diagnosis has been made, there are a number of things to consider regarding a management plan.

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  • PERTs are the basis of therapy for treatment of EPI
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Lifestyle Modifications

  • Eating a well-balanced diet
  • Avoiding or limiting alcohol intake
  • Smoking cessation
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Vitamin Supplements

  • Consider vitamin supplementation, including fat-soluble vitamins A, D, E, and K

References: 1. Domínguez-Muñoz JE. Pancreatic enzyme therapy for pancreatic exocrine insufficiency. Curr Gastroenterol Rep. 2007;9(2):116-122. 2. Fieker A, Philpott J, Armand M. Enzyme replacement therapy for pancreatic insufficiency: present and future. Clin Exp Gastroenterol. 2011;4:55-73. 3. Lindkvist B. Diagnosis and treatment of pancreatic exocrine insufficiency. World J Gastroenterol. 2013;19(42):7258-7266. 4. US Food and Drug Administration. Guidance for Industry Exocrine Pancreatic Insufficiency Drug Products – Submitting NDAs. April 2006. https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071651.pdf. Accessed October 31, 2018. 5. Cystic Fibrosis Foundation. Use of Pancreatic Enzyme Supplements for Patients with Cystic Fibrosis in the Context of Fibrosing Colonopathy. Paper presented at the: Consensus Conference; March 23, 1995. Accessed August 20, 2018. 6. Data on file. AbbVie Inc. Source: SHS data (2015-2017), 2017. 7. Windsor JA. Pancreatic enzyme replacement therapy in chronic pancreatitis: a long way to go. Gut. 2017;66(8):1354-1355.