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EPI is a manageable condition1-4

Once you have made a diagnosis of EPI, a comprehensive management plan should include pancreatic enzyme replacement therapy (PERT), certain lifestyle modifications, and potentially vitamin supplementation. PERT is the standard of care for EPI treatment.

Comprehensive EPI management plan1-4

Once an EPI diagnosis has been made, there are a number of things to consider regarding a management plan.

Icon of a pill bottle and pill Icon of a pill bottle and pill


  • PERTs are the standard of care for EPI treatment
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Lifestyle Modifications

  • Eating a well-balanced diet
  • Avoiding or limiting alcohol intake
  • Smoking cessation
Vitamin supplement bottles Vitamin supplement bottles

Vitamin Supplements

  • Consider vitamin supplementation, including fat-soluble vitamins A, D, E, and K

References: 1. Domínguez-Muñoz JE. Pancreatic enzyme therapy for pancreatic exocrine insufficiency. Curr Gastroenterol Rep. 2007;9(2):116-122. 2. Fieker A, Philpott J, Armand M. Enzyme replacement therapy for pancreatic insufficiency: present and future. Clin Exp Gastroenterol. 2011;4:55-73. 3. Lindkvist B. Diagnosis and treatment of pancreatic exocrine insufficiency. World J Gastroenterol. 2013;19(42):7258-7266. 4. Taylor JR, Gardner TB, Waljee AK, Dimagno MJ, Schoenfeld PS. Systematic review: efficacy and safety of pancreatic enzyme supplements for exocrine pancreatic insufficiency. Aliment Pharmacol Ther. 2010;31(1):57-72. 5. Pancreatic Cancer Action Network. Pancreatic enzymes.,it%20enters%20the%20small%20intestine. Accessed December 15, 2020. 6. Cystic Fibrosis Foundation. Use of Pancreatic Enzyme Supplements for Patients with Cystic Fibrosis in the Context of Fibrosing Colonopathy. Paper presented at the: Consensus Conference; March 23, 1995. Accessed August 20, 2018. 7. Data on file. AbbVie Inc. Source: SHS data (2018-2020), 2020. 8. Windsor JA. Pancreatic enzyme replacement therapy in chronic pancreatitis: a long way to go. Gut. 2017;66(8):1354-1355.