Underlying Conditions and

EPI can result from various etiologies

Exocrine Pancreatic Insufficiency (EPI) is caused by inadequate production, delivery, or activity of the pancreatic enzymes needed for digestion.1

Image conveying decreased production of pancreatic enzymes in pancreas

Decreased production of pancreatic enzymes2,3

Loss of functional pancreatic parenchyma or reduced endogenous stimulation of the pancreas can result in decreased production of enzymes.

Image conveying decreased delivery of pancreatic enzymes to the duodenum

Decreased delivery of pancreatic enzymes to the duodenum2,3

An obstruction in the duct can cause a decrease in the delivery of pancreatic enzymes to the duodenum.

Image conveying decreased activity of pancreatic enzymes

Decreased activity of pancreatic enzymes2,3

Activity of enzymes can be reduced due to postcibal asynchrony or intraluminal activation.

EPI may be present in patients with the following underlying conditions or procedures:

Other underlying conditions and procedures in which EPI has been reported include:

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